Uric Acid And Ascorbic Acid Levels In Pregnancy With Preeclampsia And Diabetes
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چکیده
Serum uric acid (SUA) and ascorbic acid levels were evaluated in 40 patients preclampsia [18-diabetic pre-eclamptic women (DM-PRW) & 22 without diabetes (PRW)]; 20 normotensive pregnant women [8 with gestational diabetes (G-DM) & rest 12 were healthy pregnant women (HPW)]; and control group consisting of 20 healthy non-pregnant women. SUA values were significantly increased in PRW & DM-PRW as compared to controls and were higher in PRW than DM-PRW (p >0.05). Also, SUA was significantly increased in G-DM as compared to HNPW (p<0.001). Serum ascorbic levels showed a significant fall in PRW and DM-PRW (p<0.01) with DM-PRW being still lower (p >0.05). Also, ascorbate levels were lowered in G-DM as compared to HNPW (p <0.001). PRW showed a significant negative correlation between ascorbate and uric acid levels (p <0.01). Thus, the elevated circulating concentration of uric acid, a valuable marker of pre-eclampsia that we propose may be a marker of free radical generation, may also serve a protective role.
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